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The IgG4 Level test measures the concentration of Immunoglobulin G4, the least common of the four subclasses of IgG antibodies. While IgG antibodies generally protect the body against infection, an abnormal elevation in the IgG4 subclass is the primary serological marker for IgG4-Related Disease (IgG4-RD), a recently recognized group of fibro-inflammatory disorders.

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