CgA is found in secretory granules of neuroendocrine cells. When these cells grow uncontrollably (forming a tumor), they release large amounts of CgA into the bloodstream.
- The Diagnostic Role: It is a “pan-neuroendocrine” marker, meaning it can be elevated in various types of NETs regardless of which specific hormone the tumor is producing.
- Tumor Burden: Generally, the higher the level of CgA in the blood, the larger the “tumor burden” (size or number of tumors).
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