The TPMT enzyme is responsible for breaking down thiopurine drugs in the body. However, some people have genetic variations (polymorphisms) that cause their TPMT enzyme to be less active or completely inactive.
- If a person with low TPMT activity takes a standard dose of these drugs, the medication builds up to toxic levels in the bone marrow, leading to myelosuppression (a dangerous drop in white blood cells, red blood cells, and platelets).
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