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When the heart’s chambers are stretched (due to fluid buildup or high pressure), the heart muscle produces a “pre-hormone” called proBNP. This molecule then splits into two pieces:

  1. BNP: The active hormone that helps the body get rid of salt and water.
  2. NT-proBNP: An inactive fragment that stays in the blood longer than BNP, making it easier to measure accurately in a lab.

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