The LKM-1 antibody targets a specific enzyme called Cytochrome P450 2D6, which is found in high concentrations in liver cells (hepatocytes) and the kidneys.
- The Autoimmune Response: While antibodies are usually meant to fight viruses, these specific proteins “auto-attack” your own liver tissue.
- Who it Affects: Unlike Type 1 Autoimmune Hepatitis (which affects adults of all ages), Type 2 (LKM-1 positive) is most commonly diagnosed in children and young women
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