Estradiol (E2) is the most potent and prevalent form of estrogen in the human body during the reproductive years. While often referred to as a “female” hormone, it is present and essential in both men and women. In premenopausal women, it is primarily produced by the ovaries; in men and postmenopausal women, it is created through the conversion of testosterone (aromatization) in fat cells and other tissues.
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