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CA 125 is a protein found on the surface of most ovarian cancer cells and is also released into the bloodstream. It is a “tumor marker”—a substance that can be measured in the blood to provide clues about what is happening inside the body. While it is most famously associated with ovarian cancer, it is not a “cancer-only” protein; it can be produced by any tissue that is irritated or inflamed, such as the lining of the abdomen (peritoneum) or the uterus.