The “P” in p-ANCA stands for Perinuclear. When these antibodies are viewed under a microscope, they cluster around the nucleus (the center) of the white blood cell.
- The “Autoimmune Friendly Fire”: Instead of fighting infections, these antibodies trigger white blood cells to release toxic substances onto the walls of blood vessels.
- The MPO Target: In clinical practice, a positive p-ANCA result usually means the body is producing antibodies against MPO, an enzyme involved in killing bacteria.
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